Article

Prediction of fluoroquinolone susceptibility directly from whole genome sequence data using liquid chromatography-tandem mass spectrometry to identify mutant genotypes

2017-05-16

Abstract excerpt

<h4>ABSTRACT</h4> Fluoroquinolone resistance in bacteria is multifactorial, involving target site mutations, reductions in fluoroquinolone entry due to reduced porin production, increased fluoroquinolone efflux, enzymes that modify fluoroquinolones, and Qnr, a DNA mimic that protects the drug target from fluoroquinolone binding. Here we report a comprehensive analysis using transformation and in vitro mutant sele...

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Literature Corpus work: 85cb091b-31d7-5929-a06c-317fc2d805c1
DOI: 10.1101/138248

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