Article
Unanticipated global emergence and evolution of Pneumocystis jirovecii mutations and resistance driven by a human-targeted drug.
Science translational medicine - 16 Sept 2026
Ma Liang, Hao Ming, Chang Weizhong, Khanal Akanchhya, Ewell Steven M, Deng Xilong, Sun Junfeng, Azar Marwan M, Cusini Alexia, Fehr Thomas, Gianella Sara, Goto Norihiko, Helweg-Larsen Jannik, Handley Grace, Hirzel Cedric, Huang Laurence, Konrad Regina, Mueller Nicolas J, Oka Shinichi, Pan Lingai, Peng Li, Rostved Andreas A, Sassi Monica, Sing Andreas, Spielman Benjamin, Walsh Laura F, Wang Yubao, Yazaki Hirohisa, Hedstrom Lizbeth, Imamichi Tomozumi, Kovacs Joseph A
Abstract excerpt
Nearly all known cases of antimicrobial resistance have been linked to agents that directly target microbes. This paradigm overlooks other drivers of microbial evolution and resistance. Here, we report compelling evidence of resistance-associated mutations in Pneumocystis jirovecii, a high-priority fungal pathogen designated by WHO as having unknown resistance. These mutations emerged under selective pressure...
Read the complete abstract on PubMedTopics
- Pneumocystis carinii
- Humans
- Mutation