Article

Unanticipated Global Emergence of Multiple<i>Pneumocystis jirovecii</i>Mutants Selected by Mycophenolic Acid Driving Increasing Outbreaks in Solid Organ Transplant Recipients

2025-06-17

Abstract excerpt

<h4>Background</h4> Classified by the WHO as one of the 19 most dangerous fungal pathogens, Pneumocystis jirovecii has been associated with increasing outbreaks of Pneumocystis pneumonia (PCP) among solid organ transplant (SOT) recipients worldwide. Mycophenolic acid (MPA), an inosine monophosphate dehydrogenase (IMPDH) inhibitor commonly used as an immunosuppressant to prevent organ rejection, is a risk factor fo...

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Literature Corpus work: 21e0a1b0-3a13-5e9f-a4f8-90ad47fc45fc
DOI: 10.1101/2025.06.17.25328583

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Unanticipated Global Emergence of Multiple<i>Pneumocystis jirovecii</i>Mutants Selected by Mycophenolic Acid Driving Increasing Outbreaks in Solid Organ Transplant RecipientsDOI 10.1101/2025.06.17.25328583Read

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