Article

Synthetic coevolution reveals adaptive mutational trajectories of neutralizing antibodies and SARS-CoV-2

2024-04-01

Abstract excerpt

<h4>ABSTRACT</h4> The Covid-19 pandemic showcases a coevolutionary race between the human immune system and SARS-CoV-2, mirroring the Red Queen hypothesis of evolutionary biology. The immune system generates neutralizing antibodies targeting the SARS-CoV-2 spike protein’s receptor binding domain (RBD), crucial for host cell invasion, while the virus evolves to evade antibody recognition. Here, we establish a synt...

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Literature Corpus work: c7255ac1-eaac-59fe-baba-a94dd5d6b0ea
DOI: 10.1101/2024.03.28.587189

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