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Article

Deep learning guided optimization of human antibody against SARS-CoV-2 variants with broad neutralization

1 Mar 2022

Abstract excerpt

SignificanceSARS-CoV-2 continues to evolve through emerging variants, more frequently observed with higher transmissibility. Despite the wide application of vaccines and antibodies, the selection pressure on the Spike protein may lead to further evolution of variants that include mutations that can evade immune response. To catch up with the virus's evolution, we introduced a deep learning approach to redesign...

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Share to Monoclonal and Polyclonal Antibodies Research
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PMID: 35238654
DOI: 10.1073/pnas.2122954119

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