Article

Heterologous Production of the D-Cycloserine Intermediate O-acetyl-L-serine in Human Lung Cancer Cells

2022-10-24

Abstract excerpt

According to the World Health Organization, Tuberculosis (TB) is the second leading cause of death by a single infectious disease behind COVID-19. Despite a century of effort, the current TB vaccine does not effectively prevent pulmonary TB, promote herd immunity, or prevent transmission. Therefore, we seek to develop a genetic prophylaxis for TB. We have determined D-cycloserine to be the optimal target for this...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c70e67cb-d9b7-5b23-aa89-84f0f814e7be
DOI: 10.21203/rs.3.rs-2180808/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Heterologous Production of the D-Cycloserine Intermediate O-acetyl-L-serine in Human Lung Cancer CellsDOI 10.21203/rs.3.rs-2180808/v1Read

Homology modeling and identification of amino acids involved in the catalytic process of Mycobacterium tuberculosis serine acetyltransferase.Semantic proximity Read

Cysteine biosynthesis in Lactobacillus casei: identification and characterization of a serine acetyltransferase.Semantic proximity Read

The therapeutic potential of D-Serine in reducing expression of the cytopathic genotoxin colibactinSemantic proximity Read

Reduced folate supply as a key to enhanced L-serine production by Corynebacterium glutamicum.Semantic proximity Read

Engineering of high yield production of L-serine in Escherichia coli.Semantic proximity Read

A Review on Molecular Functional and Structural Characterization of Human Cysteine Cathepsins in Bacterial Expression SystemsSemantic proximity Read

The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.Semantic proximity Read

Active-Site Engineering Expands the Substrate Profile of the Basidiomycete L-Tryptophan Decarboxylase CsTDC.Semantic proximity Read

Mutation of N304 to leucine in Streptomyces clavuligerus deacetoxycephalosporin C synthase creates an enzyme with increased penicillin analogue conversion.Semantic proximity Read

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine.Semantic proximity Read

Systematic engineering of synthetic serine cycles in Pseudomonas putida uncovers emergent topologies for methanol assimilationSemantic proximity Read

A novel aceE mutation leading to a better growth profile and a higher L-serine production in a high-yield L-serine-producing Corynebacterium glutamicum strain.Semantic proximity Read