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Article

The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.

The FEBS journal - 1 Sept 2018

Giardina Giorgio, Paone Alessio, Tramonti Angela, Lucchi Roberta, Marani Marina, Magnifico Maria Chiara, Bouzidi Amani, Pontecorvi Valentino, Guiducci Giulia, Zamparelli Carlotta, Rinaldo Serena, Paiardini Alessandro, Contestabile Roberto, Cutruzzolà Francesca

Abstract excerpt

Cancer cells reprogramme one-carbon metabolism (OCM) to sustain growth and proliferation. Depending on cell demands, serine hydroxymethyltransferase (SHMT) dynamically changes the fluxes of OCM by reversibly converting serine and tetrahydrofolate (THF) into 5,10-methylene-THF and glycine. SHMT is a tetrameric enzyme that mainly exists in three isoforms; two localize in the cytosol (SHMT1/SHMT2α) and one (SHMT2)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 30035852
DOI: 10.1111/febs.14610

Genes

SHMT1
OCM
SHMT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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