Article
Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2009
Eustáquio Alessandra S, McGlinchey Ryan P, Liu Yuan, Hazzard Christopher, Beer Laura L, Florova Galina, Alhamadsheh Mamoun M, Lechner Anna, Kale Andrew J, Kobayashi Yoshihisa, Reynolds Kevin A, Moore Bradley S
Abstract excerpt
Polyketides are among the major classes of bioactive natural products used to treat microbial infections, cancer, and other diseases. Here we describe a pathway to chloroethylmalonyl-CoA as a polyketide synthase building block in the biosynthesis of salinosporamide A, a marine microbial metabolite whose chlorine atom is crucial for potent proteasome inhibition and anticancer activity. S-adenosyl-L-methionine...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.