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Article

Integrated Multiomics Approach to Identify Genetic Underpinnings of Heart Failure and Its Echocardiographic Precursors: Framingham Heart Study.

Circulation. Genomic and precision medicine - 1 Dec 2019

Andersson Charlotte, Lin Honghuang, Liu Chunyu, Levy Daniel, Mitchell Gary F, Larson Martin G, Vasan Ramachandran S

Abstract excerpt

BACKGROUND: Heart failure (HF) may arise from alterations in metabolic, structural, and signaling pathways, but its genetic architecture is incompletely understood. To elucidate potential genetic contributors to cardiac remodeling and HF, we integrated genome-wide single-nucleotide polymorphisms, gene expression, and DNA methylation using a transomics analytical approach. METHODS: We used robust rank aggregation...

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PMID: 31703168
DOI: 10.1161/CIRCGEN.118.002489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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