Integrative multi-omics QTL colocalization maps regulatory architecture in aging human brain

Abstract excerpt

Multi-trait QTL (xQTL) colocalization has shown great promises in identifying causal variants with shared genetic etiology across multiple molecular modalities, contexts, and complex diseases. However, the lack of scalable and efficient methods to integrate large-scale multi-omics data limits deeper insights into xQTL regulation. Here, we propose ColocBoost , a multi-task learning colocalization method that can s...

Topics

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• Dementia and Cognitive Impairment Research
• Genetic Associations and Epidemiology
• Genetic Pleiotropy
• Genome-Wide Association Study
• Multifactorial Inheritance
• Phenotype
• Polymorphism, Single Nucleotide
• Quantitative Trait Loci

Identifiers and source

Literature Corpus work

c6e63f08-701a-5217-9ad9-6938c4ed3e83

DOI

10.1101/2025.04.17.25326042