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Article

Statistical examination of shared loci in neuropsychiatric diseases using genome-wide association study summary statistics.

eLife - 17 Dec 2024

Spargo Thomas P, Gilchrist Lachlan, Hunt Guy P, Dobson Richard J B, Proitsi Petroula, Al-Chalabi Ammar, Pain Oliver, Iacoangeli Alfredo

Abstract excerpt

Continued methodological advances have enabled numerous statistical approaches for the analysis of summary statistics from genome-wide association studies. Genetic correlation analysis within specific regions enables a new strategy for identifying pleiotropy. Genomic regions with significant 'local' genetic correlations can be investigated further using state-of-the-art methodologies for statistical fine-mapping...

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Identifiers

PMID: 39688956
DOI: 10.7554/eLife.88768
PMCID: PMC11651651

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