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Computational identification of potential modulators of heme-regulated inhibitor (HRI) for pharmacological intervention against sickle cell disease

2023-12-15

Abstract excerpt

<title>Abstract</title><p>Background Sickle cell disease (SCD) poses a significant health challenge and therapeutic approaches often target fetal hemoglobin (HbF) to ameliorate symptoms. Hydroxyurea, a current therapeutic option for SCD, has shown efficacy in increasing HbF levels. However, concerns about myelosuppression and thrombocytopenia necessitate the exploration of alternative compounds. Heme-regulated inh...

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Literature Corpus work
c6e3f83b-0d03-50be-9b4d-a8140c6e2040
DOI
10.21203/rs.3.rs-3755458/v1
Open publication

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Computational identification of potential modulators of heme-regulated inhibitor (HRI) for pharmacological intervention against sickle cell diseaseDOI 10.21203/rs.3.rs-3755458/v1
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