Article

Insilico identification of a ferroportin inhibitor for the management of iron-overload condition in Beta Thalassemia major patients.

2021-03-30

Abstract excerpt

<title>Abstract</title> The reason of high mortality rate in the patients of beta-thalassemia major is iron overload because it leads to many secondary complications. Condition of iron overload is known as hemochromatosis (HC). HC causes distorted formation of HFE protein that disturbs the whole pathway of HAMP protein synthesis which results in unbounded form of ferroportin and hence iron keeps absorbing in t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5335a273-2e92-572b-8020-774eaa6ab316
DOI: 10.21203/rs.3.rs-241407/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Insilico identification of a ferroportin inhibitor for the management of iron-overload condition in Beta Thalassemia major patients.DOI 10.21203/rs.3.rs-241407/v1Read

Computational identification of potential modulators of heme-regulated inhibitor (HRI) for pharmacological intervention against sickle cell diseaseSemantic proximity Read

In Silico Drug Discovery: Unveiling Potential Targets in Plasmodium falciparum through Molecular Docking AnalysisSemantic proximity Read

The recent advances of chemical biology in artemisinin target and mechanismSemantic proximity Read

Elucidation of the Inhibitory Effect of Phytochemicals with Kir6.2 Wild-Type and Mutant Models Associated in Type-1 Diabetes through Molecular Docking ApproachSemantic proximity Read

Antidiabetic Drugs and Target Prediction on Human for Type 2 Diabetes Mellitus: A Minireview of Pharmacological ProfileSemantic proximity Read

Screening and identification of phytochemical drug molecules against mutant BRCA1 receptor of breast cancer using computational approaches.Semantic proximity Read

Pharmacoinformatics-based prediction of potential Keap1 inhibitors from Hemidesmus indicus (L) R.Br. against oxidative stress-induced diseasesSemantic proximity Read

Open access in silico tools to predict the ADMET profiling and PASS (Prediction of Activity Spectra for Substances of Bioactive compounds of Garlic (Allium sativum L.)Semantic proximity Read

In silico Repositioning of Approved Drugs Against Schistosoma mansoni Energy Metabolism TargetsSemantic proximity Read

Analysis of Plant-derived Phytochemicals as Anti-cancer Agents Targeting Cyclin Dependent Kinase-2, Human Topoisomerase IIa and Vascular Endothelial Growth Factor Receptor-2Semantic proximity Read

In silico drug discovery: Unveiling potential targets in Plasmodium falciparumSemantic proximity Read