Article
The "Achilles' Heel" of Cancer and Its Implications for the Development of Novel Immunotherapeutic Strategies.
Cold Spring Harbor perspectives in medicine - 2 Jan 2018
Joshi Kroopa, Chain Benjamin M, Peggs Karl S, Quezada Sergio A
Abstract excerpt
Over the last century, scientists have embraced the idea of mobilizing antitumor immune responses in patients with cancer. In the last decade, we have seen the rebirth of cancer immunotherapy and its validation in a series of high profile clinical trials following the discovery of several immune-regulatory receptors. Recent studies point toward the tumor mutational load and resulting neoantigen burden as being...
Topics
- Animals
- Antigens, Neoplasm
- Antineoplastic Agents, Immunological
- Humans
- Immunity, Humoral
- Immunologic Surveillance
- Immunotherapy
- Mutation
- Neoplasms
- Tumor Microenvironment