Article
The cancer-immunity cycle: Indication, genotype, and immunotype.
Immunity - 10 Oct 2023
Mellman Ira, Chen Daniel S, Powles Thomas, Turley Shannon J
Abstract excerpt
The cancer-immunity cycle provides a framework to understand the series of events that generate anti-cancer immune responses. It emphasizes the iterative nature of the response where the killing of tumor cells by T cells initiates subsequent rounds of antigen presentation and T cell stimulation, maintaining active immunity and adapting it to tumor evolution. Any step of the cycle can become rate-limiting,...
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