Article

Ultra-dynamic assemblies of glycolytic enzymes by quinary determinants

2025-10-03

Abstract excerpt

<title>Abstract</title> <p>Molecular channelling has long since been proposed as an amenable solution to efficiently drive sequential enzymatic reactions in the cell 1. Nonetheless, metabolic channelling in central pathways such as glycolysis is still a matter of debate and plausible underlying mechanisms are not known 2,3. Here we use correlation spectroscopy and proximity labelling methods to uncover extremely...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c6d0e42b-2dbc-547c-9968-ed8b5086b46c
DOI: 10.21203/rs.3.rs-7387153/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ultra-dynamic assemblies of glycolytic enzymes by quinary determinantsDOI 10.21203/rs.3.rs-7387153/v1Read

Breaking Glycolysis: Allosteric Hotspots for Multi-Target Drug RepurposingSemantic proximity Read

Design Glutamate Dehydrogenase for Nonaqueous System by Motifs Reassembly and Interaction Network Analysis.Semantic proximity Read

Evolution of Protein Regulation in the Vertebrate Glucose SensorSemantic proximity Read

Pathway swapping: Toward modular engineering of essential cellular processes.Semantic proximity Read

ATP-sensitive K+ channel channel/enzyme multimer: metabolic gating in the heart.Semantic proximity Read

Protein–Protein Interactions in Multienzyme MegasynthetasesSemantic proximity Read

Correlating membrane-protein dynamics with function: Integrating bioinformatics, molecular dynamics, and single-molecule FRETSemantic proximity Read

Ultra-fast genetically encoded sensor for precise real-time monitoring of physiological and pathophysiological peroxide dynamicsSemantic proximity Read

Structure-guided engineering of a fast genetically encoded sensor for real-time H <sub>2</sub> O <sub>2</sub> monitoringSemantic proximity Read

Protometabolically generated NADH mediates material properties of aqueous dispersions to coacervate microdropletsSemantic proximity Read

Diverging co-translational protein complex assembly pathways are governed by interface energy distributionSemantic proximity Read

Protonation- and substrate-regulated dimer opening couples brain-type creatine kinase to vesicular and actin-remodeling membranesSemantic proximity Read