Article

Mouse models of non-dystrophic and dystrophic myotonia exhibit nociplastic pain-like behaviors

2024-06-22

Abstract excerpt

Pain is a prominent and debilitating symptom in myotonic disorders, including myotonia congenita and myotonic dystrophy type 1 (DM1). Although patients frequently report chronic pain, its underlying mechanisms remain poorly defined. In both disorders, impaired chloride conductance through voltage-gated CLC-1 chloride channels in skeletal muscle disrupts membrane repolarization, leading to delayed relaxation and pe...

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Literature Corpus work: c6a4568f-4ba5-52a6-9590-767b9fcb0792
DOI: 10.1101/2024.06.19.599732

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