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Article

Beneficial effects of bumetanide in a CaV1.1-R528H mouse model of hypokalaemic periodic paralysis.

Brain : a journal of neurology - 1 Dec 2013

Wu Fenfen, Mi Wentao, Cannon Stephen C

Abstract excerpt

Transient attacks of weakness in hypokalaemic periodic paralysis are caused by reduced fibre excitability from paradoxical depolarization of the resting potential in low potassium. Mutations of calcium channel and sodium channel genes have been identified as the underlying molecular defects that cause instability of the resting potential. Despite these scientific advances, therapeutic options remain limited. In a...

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Identifiers

PMID: 24142145
DOI: 10.1093/brain/awt280
PMCID: PMC3859222

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