Article

Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments

2024-01-30

Abstract excerpt

<title>Abstract</title> <p>A wide range of human disorders, including Alzheimer’s disease (AD), are characterised by the aberrant formation of amyloid fibrils. Amyloid fibrils are filamentous structures characterized by the presence of a highly-ordered cross-β core. In many cases, this core structure is flanked by disordered regions, often referred to as fuzzy coat. The structural properties of fuzzy coats, and t...

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Literature Corpus work: c69c54da-fad1-5c8e-89ab-8ca3de4a4589
DOI: 10.21203/rs.3.rs-3847495/v1

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