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Examining the Ensembles of Amyloid- <i>β</i> Monomer Variants and their Propensities to Form Fibers Using an Energy Landscape Visualization Method

2021-10-31

Abstract excerpt

The amyloid- β (A β ) monomer, an intrinsically disordered peptide, is produced by the cleavage of the amyloid precursor protein, leading to A β 40 and A β 42 as major products. These two isoforms generate pathological aggregates, whose accumulation correlates with Alzheimer’s disease (AD). Experiments have shown that even though the natural abundance of A β 42 is smaller than that for A β 40, the A β 42 is...

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Literature Corpus work: 1ed1c4e7-a3d6-5519-82ce-29943f83208f
DOI: 10.1101/2021.10.28.466349

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