Article
A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders.
Nature neuroscience - 1 Dec 2025
Smeland Olav B, Kutrolli Gleda, Bahrami Shahram, Fominykh Vera, Parker Nadine, Fuhrer Julian, Hindley Guy F L, Rødevand Linn, Jaholkowski Piotr, Tesfaye Markos, Parekh Pravesh, Elvsåshagen Torbjørn, Grotzinger Andrew D, Steen Nils Eiel, van der Meer Dennis, O'Connell Kevin S, Djurovic Srdjan, Dale Anders M, Shadrin Alexey A, Frei Oleksandr, Andreassen Ole A
Abstract excerpt
Although neurological and psychiatric disorders have historically been considered to reflect distinct pathogenic entities, recent findings suggest shared pathophysiological mechanisms. However, the extent to which these heritable disorders share genetic influences remains unclear. Here we performed a comprehensive analysis of genome-wide association study data, involving nearly 1 million cases across ten...
Read the complete abstract on PubMedTopics
- Humans
- Genome-Wide Association Study
- Mental Disorders
- Genetic Predisposition to Disease