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Quantitative prediction of nonsense-mediated mRNA decay across human genes by genomic language model and large-scale mutational scanning

2026-03-26

Abstract excerpt

The molecular consequences of protein truncating variants depend strongly on whether their transcripts are eliminated by nonsense-mediated mRNA decay (NMD), yet NMD is still predicted largely from a small set of binary positional rules. How individual premature termination codons (PTCs) engage NMD across genes and transcript contexts therefore remains incompletely resolved. Here we integrated endogenous allele-spe...

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Literature Corpus work
77108a61-eb46-59d9-b0eb-b2f44f9a210f
DOI
10.64898/2026.03.24.714003
Open publication

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Quantitative prediction of nonsense-mediated mRNA decay across human genes by genomic language model and large-scale mutational scanningDOI 10.64898/2026.03.24.714003
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