Article
IDH mutations: genotype-phenotype correlation and prognostic impact.
BioMed research international - 1 Jan 2014
Wang Xiao-Wei, Ciccarino Pietro, Rossetto Marta, Boisselier Blandine, Marie Yannick, Desestret Virginie, Gleize Vincent, Mokhtari Karima, Sanson Marc, Labussière Marianne
Abstract excerpt
IDH1/2 mutation is the most frequent genomic alteration found in gliomas, affecting 40% of these tumors and is one of the earliest alterations occurring in gliomagenesis. We investigated a series of 1305 gliomas and showed that IDH mutation is almost constant in 1p19q codeleted tumors. We found that the distribution of IDH1(R132H) , IDH1(nonR132H) , and IDH2 mutations differed between astrocytic, mixed, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.