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Article

Clinical and Molecular Features of Patients with Gliomas Harboring IDH1 Non-canonical Mutations: A Systematic Review and Meta-Analysis.

Advances in therapy - 1 Jan 2022

Di Nunno Vincenzo, Franceschi Enrico, Tosoni Alicia, Gatto Lidia, Maggio Ilaria, Lodi Raffaele, Angelini Daniele, Bartolini Stefania, Brandes Alba Ariela

Abstract excerpt

INTRODUCTION: The canonical isocitrate dehydrogenase 1 R132 mutation (IDH1 R132) is the most frequent mutation among IDH-mutated gliomas. Non-canonical IDH1 mutations or IDH2 mutations are unusual and their clinical and biological role is still unclear. METHODS: We performed a systematic review and meta-analysis to assess the clinical role of IDH non-canonical mutations. RESULTS: Overall, we selected 13 of 3513...

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Identifiers

PMID: 34853984
DOI: 10.1007/s12325-021-01977-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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