Article

Fentanyl blockade of K <sup>+</sup> channels contribute to Wooden Chest Syndrome

2025-01-18

Abstract excerpt

Fentanyl is a potent synthetic opioid widely used perioperatively and illicitly as a drug of abuse 1,2 . It is well established that fentanyl acts as a μ-opioid receptor agonist, signaling through Gα i/o intracellular pathways to inhibit electrical excitability, resulting in analgesia and respiratory depression 3,4 . However, fentanyl uniquely also triggers muscle rigidity, including respiratory muscles, hinder...

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Literature Corpus work: c6363a34-8b11-5fb6-a713-7a79cd110df8
DOI: 10.1101/2025.01.17.633656

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