Article

GABAA receptor mediated facilitation of proprioceptive afferent transmission to motoneurons is facilitated by TRPM8 channels on C-fibres that are gated by serotonin

2026-02-05

Abstract excerpt

<h4>ABSTRACT</h4> Sensory transmission in the monosynaptic stretch reflex (MSR) from proprioceptive Ia afferents to motoneurons is markedly inhibited by serotonin, providing a mechanism by which the brain gates spinal cord function. However, the main serotonin receptor subtype that modulates the MSR is the 5-HT1D receptor that is expressed almost exclusively on nociceptive C-fibres, suggesting an unexpected gatin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: db0011d9-df8e-5a05-b288-53f5f693dc45
DOI: 10.64898/2026.02.02.703408

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GABAA receptor mediated facilitation of proprioceptive afferent transmission to motoneurons is facilitated by TRPM8 channels on C-fibres that are gated by serotoninDOI 10.64898/2026.02.02.703408Read

Targeting G <sub>i/o</sub> -coupled GPCRs to inhibit nociceptors: insights from the serotonin receptor Htr1b and triptansSemantic proximity Read

The Hoffmann ReflexSemantic proximity Read

Presynaptic inhibition of cutaneous afferents prevents self-generated itchSemantic proximity Read

Molecular Identification of Pro-Excitogenic Receptor and Channel Phenotypes of the Deafferented Lumbar Motoneurons in the Early Phase after SCT in Rats.Semantic proximity Read

Nucleus raphe magnus serotonin neurons bidirectionally control spinal nociceptive transmission in miceSemantic proximity Read

GABA facilitates spike propagation through branch points of sensory axons in the spinal cordSemantic proximity Read

Excitatory drive to spinal motoneurones is necessary for serotonin to modulate motoneurone excitability via 5-HT <sub>2</sub> receptors in humansSemantic proximity Read

What would 5-HT do? Regional diversity of 5-HT(1) receptor modulation of primary afferent neurotransmission.Semantic proximity Read

Chronic Pain: Alterations of Functional StructuresSemantic proximity Read

The variability of nociplastic and central pain definition in literature: a scoping reviewSemantic proximity Read

Neuropathy following spinal nerve injury shares features with the irritable nociceptor phenotype: A back-translational study of oxcarbazepine.Semantic proximity Read

[Migraine--mechanisms and consequences for treatment].Semantic proximity Read