Article
New vistas in opioid control of pain.
Current opinion in pharmacology - 1 Feb 2012
Mizoguchi Hirokazu, Watanabe Chizuko, Sakurada Tsukasa, Sakurada Shinobu
Abstract excerpt
The μ-opioid receptors mainly contribute to the control of pain transmission, while a number of splice variants may have different physiological roles. In fact, some μ-opioid receptor agonists show distinct antinociceptive properties probably mediated via splice variants insensitive to traditional μ-opioid receptor agonists. These atypical μ-opioid receptor agonists are extremely effective against...
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