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Article

Analgesia linked to Nav1.7 loss of function requires µ- and δ-opioid receptors

16 Aug 2018

Abstract excerpt

<h4>Background: </h4> Functional deletion of the Scn9a (sodium voltage-gated channel alpha subunit 9) gene encoding sodium channel Nav1.7 makes humans and mice pain-free. Opioid signalling contributes to this analgesic state. We have used pharmacological and genetic approaches to identify the opioid receptors involved in this form of analgesia. We also examined the regulation of proenkephalin expression by the...

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PMID: 30271888
DOI: 10.12688/wellcomeopenres.14687.1

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