Article
Polygenic Risk Associations with Clinical Characteristics and Recurrence of Dupuytren Disease.
Plastic and reconstructive surgery - 1 Mar 2024
Riesmeijer Sophie A, Nolte Ilja M, Olde Loohuis Loes M, Reus Lianne M, Boltz Toni, Ng Michael, Furniss Dominic, Werker Paul M N, Ophoff Roel A
Abstract excerpt
BACKGROUND: Dupuytren disease (DD) is a common complex trait, with varying severity and incompletely understood cause. Genome-wide association studies (GWAS) have identified risk loci. In this article, we examine whether genetic risk profiles of DD in patients are associated with clinical variation and disease severity and with patient genetic risk profiles of genetically correlated traits, including body mass...
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