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Article

A Genome-wide Association Study of Dupuytren Disease Reveals 17 Additional Variants Implicated in Fibrosis.

American journal of human genetics - 7 Sept 2017

Ng Michael, Thakkar Dipti, Southam Lorraine, Werker Paul, Ophoff Roel, Becker Kerstin, Nothnagel Michael, Franke Andre, Nürnberg Peter, Espirito-Santo Ana Isabel, Izadi David, Hennies Hans Christian, Nanchahal Jagdeep, Zeggini Eleftheria, Furniss Dominic

Abstract excerpt

Individuals with Dupuytren disease (DD) are commonly seen by physicians and surgeons across multiple specialties. It is an increasingly common and disabling fibroproliferative disorder of the palmar fascia, which leads to flexion contractures of the digits, and is associated with other tissue-specific fibroses. DD affects between 5% and 25% of people of European descent and is the most common inherited disease of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28886342
DOI: 10.1016/j.ajhg.2017.08.006
PMCID: PMC5591021

Genes

SFRP4

Provenance

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