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Article

Major Genetic Risk Factors for Dupuytren's Disease Are Inherited From Neandertals.

Molecular biology and evolution - 1 Jun 2023

Ågren Richard, Patil Snehal, Zhou Xiang, Sahlholm Kristoffer, Pääbo Svante, Zeberg Hugo

Abstract excerpt

Dupuytren's disease is characterized by fingers becoming permanently bent in a flexed position. Whereas people of African ancestry are rarely afflicted by Dupuytren's disease, up to ∼30% of men over 60 years suffer from this condition in northern Europe. Here, we meta-analyze 3 biobanks comprising 7,871 cases and 645,880 controls and find 61 genome-wide significant variants associated with Dupuytren's disease. We...

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Identifiers

PMID: 37315093
DOI: 10.1093/molbev/msad130
PMCID: PMC10266526

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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