Article

Ribosomal S6 kinase 1 regulates ‘inflammaging’ via the senescence secretome

2023-10-20

Abstract excerpt

<h4>ABSTRACT</h4> Inhibition of the nutrient-responsive mTOR (mammalian target of rapamycin) signalling pathway including the key downstream effector S6 kinase 1 (S6K1) extends lifespan and improves healthspan in mice. However, the underlying mechanisms contributing to the broad range of age-related benefits observed with loss of S6K1 signalling are unclear. Cellular senescence is a stable growth arrest accompani...

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Literature Corpus work: c602f9c5-8cc9-5f61-9331-dcf74878280e
DOI: 10.1101/2023.10.17.562098

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