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Article

Klotho suppresses RIG-I-mediated senescence-associated inflammation.

Nature cell biology - 1 Mar 2011

Liu Feng, Wu Su, Ren Hongwei, Gu Jun

Abstract excerpt

It is well known that aged or senescent cells develop a complex senescence-associated secretory phenotype (SASP), which is observed both in culture and in vivo. However, the mechanisms underlying the induction of the SASP are largely unknown. We demonstrate that retinoic-acid-inducible gene-I (RIG-I) is induced through the ataxia telangiectasia mutated-interferon regulatory factor 1 (ATM-IRF1) axis in senescent...

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PMID: 21336305
DOI: 10.1038/ncb2167

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ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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