Article
Mutations in the rotavirus spike protein VP4 reduce trypsin sensitivity but not viral spread.
The Journal of general virology - 1 Jun 2013
Trask Shane D, Wetzel J Denise, Dermody Terence S, Patton John T
Abstract excerpt
Infectious entry of the nonenveloped rotavirus virion requires proteolysis of the spike protein VP4 to mediate conformational changes associated with membrane penetration. We sequenced and characterized an isolate that was cultured in the absence of trypsin and found that it is more resistant to proteolysis than WT virus. A substitution mutation abrogates one of the defined trypsin-cleavage sites, suggesting that...
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