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CRISPR-Csy4-Mediated Editing of Rotavirus Double-Stranded RNA Genome

1 Sept 2020

Abstract excerpt

CRISPR-nucleases have been widely applied for editing cellular and viral genomes, but nuclease-mediated genome editing of double-stranded RNA (dsRNA) viruses has not yet been reported. Here, by engineering CRISPR-Csy4 nuclease to localize to rotavirus viral factories, we achieve the nuclease-mediated genome editing of rotavirus, an important human and livestock pathogen with a multisegmented dsRNA genome....

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PMID: 32997981
DOI: 10.1016/j.celrep.2020.108205

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