Article

<i>In vitro</i> and <i>In vivo</i> Genetic Disease Modelling via NHEJ-precise deletions using CRISPR/Cas9

2020-03-26

Abstract excerpt

<h4>ABSTRACT</h4> Development of advanced gene and cell therapies for the treatment of genetic diseases requires confident animal and cellular models to test their efficacy and is crucial in the cases where no primary samples from patients are available. CRISPR/Cas9 technology, has become one of the most spread endonuclease tools for editing the genome at will. Moreover, it is known that the use of two guides ten...

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Literature Corpus work: c5fc4acb-d671-569c-9c2e-d358ad3c8816
DOI: 10.1101/2020.03.25.007260

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