NT5E Promotes Colorectal Cancer Progression and Correlates with PD-L1 Expression: Evidence from Multi-Omics Analysis, Clinical Samples, and Cellular Functional Assays

Abstract excerpt

<title>Abstract</title> <p>Background Extracellular 5'-nucleotidase (NT5E/CD73) plays a pivotal role in the tumor immune microenvironment by catalysing the production of adenosine. This study aims to evaluate the expression and function of NT5E in colorectal cancer progression, and to explore its potential as a novel biomarker and for associated immunotherapy. Methods Genomic alterations, prognostic significanc...

Topics

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• Adenosine and Purinergic Signaling
• Carcinoma, Neuroendocrine
• CD8-Positive T-Lymphocytes
• Chemokine CCL5
• Colorectal Neoplasms
• Fibroblast Growth Factor Research
• Gene Expression Regulation, Neoplastic
• Neuroendocrine Tumor Research Advances

Identifiers and source

Literature Corpus work

c5d8b3fd-8be1-5926-8b63-0a1c35a2ed97

DOI

10.21203/rs.3.rs-9339416/v1