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Protein expression of the amino acid transporter SLC7A5 in tumor tissue is prognostic in early-stage colorectal cancer

9 May 2024

Abstract excerpt

Proteins overexpressed in early-stage cancers may serve as early diagnosis and prognosis markers as well as targets for cancer therapies. In this study, we examined the expression of an essential amino acid carrier SLC7A5 (LAT1, CD98, or 4F2 light chain) in cancer tissue from two well-annotated cohorts of 575 cases of early-stage and 106 cases of late-stage colorectal cancer patients. Immunohistochemistry showed...

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Amino Acid Enzymes and Metabolism
Drug Transport and Resistance Mechanisms
Epigenetics and DNA Methylation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38722983
DOI: 10.1371/journal.pone.0298362

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