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Pan-cancer analysis identifies NT5E as a novel prognostic biomarker on cancer-associated fibroblasts associated with unique tumor microenvironment

7 Dec 2022

Abstract excerpt

Background: Ecto-5′-nucleotidase (NT5E) encodes the cluster of differentiation 73 (CD73), whose overexpression contributes to the formation of immunosuppressive tumor microenvironment and is related to exacerbated prognosis, increased risk of metastasis and resistance to immunotherapy of various tumors. However, the prognostic significance of NT5E in pan-cancer is obscure so far. Methods: We explored the...

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PMID: 36569293
DOI: 10.3389/fphar.2022.1064032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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