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F2,6BP restores mitochondrial genome integrity in Huntington’s Disease

2024-11-04

Abstract excerpt

Several reports have indicated that impaired mitochondrial function contributes to the development and progression of Huntington’s disease (HD). Mitochondrial genome damage, particularly DNA strand breaks, is a potential cause for its compromised functionality. Here we show that the activity of polynucleotide kinase 3’-phosphatase (PNKP), a critical DNA end-processing enzyme, is significantly decreased in the mito...

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Identifiers and source

Literature Corpus work
f27532dd-5e44-536e-a088-8f282ff297f1
DOI
10.1101/2024.11.04.621834
Open publication

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F2,6BP restores mitochondrial genome integrity in Huntington’s DiseaseDOI 10.1101/2024.11.04.621834
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