Article

TBK1 interacts with tau and enhances neurodegeneration in tauopathy

2020-06-18

Abstract excerpt

<h4>ABSTRACT</h4> One of the defining pathological features of Alzheimer’s Disease (AD) is the deposition of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau in the brain. Aberrant activation of kinases in AD has been suggested to enhance phosphorylation and toxicity of tau, making the responsible tau-directed kinases attractive therapeutic targets. The full complement of tau interacting kinases...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ab3902b4-7242-5468-8b6b-80df53356869
DOI: 10.1101/2020.06.17.157552

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TBK1 interacts with tau and enhances neurodegeneration in tauopathyDOI 10.1101/2020.06.17.157552Read

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathiesSemantic proximity Read

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.Semantic proximity Read

MARK4 with an Alzheimer’s disease-related mutation promotes tau hyperphosphorylation directly and indirectly and exacerbates neurodegenerationSemantic proximity Read

Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in TauopathySemantic proximity Read

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegenerationSemantic proximity Read

TBK1 haploinsufficiency results in changes in the K63-ubiquitination profiles in brain and fibroblasts from affected and presymptomatic mutation carriers.Semantic proximity Read

Phosphorylated tau interactome in the human Alzheimer’s disease brainSemantic proximity Read

TDP-43 subcellular mislocalisation is correlated with loss of optineurin binding for frontotemporal dementia and amyotrophic lateral sclerosis associated <i>TBK1</i> missense variantsSemantic proximity Read

Co-occurrence of multiple pathologies in a case of frontotemporal dementia with TBK1 mutation: first in vivo detection of alpha-synuclein and tau co-pathology.Semantic proximity Read

Physiological Tau Interactome in Brain and Its Link to TauopathiesSemantic proximity Read

TBK1: a new player in ALS linking autophagy and neuroinflammationSemantic proximity Read

Functional and structural consequences of TBK1 missense variants in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.Semantic proximity Read