Article
A novel partially open state of SHP2 points to a "multiple gear" regulation mechanism.
The Journal of biological chemistry - 1 Jan 2000
Tao Youqi, Xie Jingfei, Zhong Qinglu, Wang Yongyao, Zhang Shengnan, Luo Feng, Wen Fengcai, Xie Jingjing, Zhao Jiawei, Sun Xiaoou, Long Houfang, Ma Junfeng, Zhang Qian, Long Jiangang, Fang Xianyang, Lu Ying, Li Dan, Li Ming, Zhu Jidong, Sun Bo, Li Guohui, Diao Jiajie, Liu Cong
Abstract excerpt
The protein tyrosine phosphatase SHP2 mediates multiple signal transductions in various cellular pathways, controlled by a variety of upstream inputs. SHP2 dysregulation is causative of different types of cancers and developmental disorders, making it a promising drug target. However, how SHP2 is modulated by its different regulators remains largely unknown. Here, we use single-molecule fluorescence resonance...
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