Article

The pathogenic E139D mutation stabilizes a non-canonical active state of the multi-domain phosphatase SHP2

2025-07-04

Abstract excerpt

Dysregulation of the phosphatase SHP2 is implicated in various diseases, including congenital disorders and cancer. SHP2 contains two phosphotyrosine-recognition domains (N-SH2 and C-SH2) and a protein tyrosine phosphatase (PTP) domain. The N-SH2 domain is critical for SHP2 regulation. In the auto-inhibited state, it binds to the PTP domain and blocks the active site, but phosphoprotein engagement destabilizes the...

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Literature Corpus work: 391da66b-3136-5f24-b9ee-7c9bb4b7da1c
DOI: 10.1101/2025.07.02.662799

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