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Article

Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2.

Nature communications - 1 Jan 2013

Sun Jie, Lu Shaoying, Ouyang Mingxing, Lin Li-Jung, Zhuo Yue, Liu Bo, Chien Shu, Neel Benjamin G, Wang Yingxiao

Abstract excerpt

Protein functions are largely affected by their conformations. This is exemplified in proteins containing modular domains. However, the evolutionary dynamics that define and adapt the conformation of such modular proteins remain elusive. Here we show that cis-interactions between the C-terminal phosphotyrosines and SH2 domain within the protein tyrosine phosphatase Shp2 can be tuned by an adaptor protein, Grb2....

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Identifiers

PMID: 23792876
DOI: 10.1038/ncomms3037
PMCID: PMC3777412

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