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The SINTER study: A Recall-by-Genotype design with multidimensional musculoskeletal phenotyping across internal-medicine outpatient clinics

2025-12-08

Abstract excerpt

<title>Abstract</title> <p> Bone mineral density (BMD) measured by DXA remains the clinical standard for diagnosing osteoporosis, but fails to capture the heterogeneity of skeletal fragility, particularly in patients with chronic diseases. We hereby describe the design of the EraSmus medIcal CeNTer skEletal fRagility (SINTER) Study, which integrates polygenic scores for BMD (PGS <sub>BMD</sub> ) with a multidi...

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Literature Corpus work: c5afb857-482b-5989-b848-847b5c6b2de8
DOI: 10.21203/rs.3.rs-8238983/v1

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