Article
Time scales in epigenetic dynamics and phenotypic heterogeneity of embryonic stem cells.
PLoS computational biology - 1 Jan 2013
Sasai Masaki, Kawabata Yudai, Makishi Koh, Itoh Kazuhito, Terada Tomoki P
Abstract excerpt
A remarkable feature of the self-renewing population of embryonic stem cells (ESCs) is their phenotypic heterogeneity: Nanog and other marker proteins of ESCs show large cell-to-cell variation in their expression level, which should significantly influence the differentiation process of individual cells. The molecular mechanism and biological implication of this heterogeneity, however, still remain elusive. We...
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