Article

Transient activation of the UPR <sup>ER</sup> is an essential step in the acquisition of pluripotency during reprogramming

2018-11-17

Abstract excerpt

Somatic cells can be reprogrammed into pluripotent stem cells by the forced expression of the OCT4, SOX2, KLF4 and c-MYC transcription factors. This process requires the reshaping of not only epigenetic landscapes, but the global remodeling of cell identity, structure, and function including such basic processes of metabolism and organelle form and function. Cellular reprogramming is a stochastic process with only...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c6c70bd5-3dc6-5d42-8cc6-c300f759ceff
DOI: 10.1101/472787

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transient activation of the UPR <sup>ER</sup> is an essential step in the acquisition of pluripotency during reprogrammingDOI 10.1101/472787Read

Conserved Biological Processes in Partial Cellular Reprogramming: A Comprehensive ReviewSemantic proximity Read

New insights into the unfolded protein response in stem cellsSemantic proximity Read

Conserved biological processes in partial cellular reprogramming: Relevance to aging and rejuvenationSemantic proximity Read

A multiscale model of epigenetic heterogeneity reveals the kinetic routes of pathological cell fate reprogrammingSemantic proximity Read

Optogenetic Clustering of Human IRE1 Reveals Differential Regulation of Transcription and mRNA Splice Isoform Abundance by the UPRSemantic proximity Read

QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasisSemantic proximity Read

Profiling of the reprogramome and quantification of fibroblast reprogramming to pluripotencySemantic proximity Read

Initial OCT4 engagement with the somatic proteome during reprogramming to iPSCSemantic proximity Read

Multi-Omic Profiling Reveals Dynamics of the Phased Progression of PluripotencySemantic proximity Read

In vivo cellular adaptation to ER stress: survival strategies with double-edged consequences.Semantic proximity Read

Stress Factors as Possible Regulators of Pluripotent Stem Cell Survival and DifferentiationSemantic proximity Read

Insulin demand regulates β cell number via the unfolded protein responseSemantic proximity Read