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Article

Understanding epigenetic changes in aging stem cells--a computational model approach.

Aging cell - 1 Apr 2014

Przybilla Jens, Rohlf Thimo, Loeffler Markus, Galle Joerg

Abstract excerpt

During aging, a decline in stem cell function is observed in many tissues. This decline is accompanied by complex changes of the chromatin structure among them changes in histone modifications and DNA methylation which both affect transcription of a tissue-specific subset of genes. A mechanistic...

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Identifiers

PMID: 24428552
DOI: 10.1111/acel.12177
PMCID: PMC4331773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24428552-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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