Article

Glutathione peroxidase 4 suppresses manganese-dependent oxidative stress to reduce colorectal tumorigenesis.

2024-01-08

Abstract excerpt

<title>Abstract</title> <p>The role of glutathione peroxidase 4 (GPX4) in ferroptosis and various cancers is well-established; however, its specific contribution to colorectal cancer has been unclear. Surprisingly, in a genetic mouse model of colon tumors, the deletion of GPX4 specifically in colon epithelial cells increased tumor burden but decreased oxidized glutathione. Notably, this specific GPX4 deletion did...

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Literature Corpus work: c59628d9-e602-5699-a1c3-82c7374eea79
DOI: 10.21203/rs.3.rs-3837925/v1

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