Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glutathione peroxidase tagSNPs: associations with rectal cancer but not with colon cancer.

Genes, chromosomes & cancer - 1 Jun 2012

Haug Ulrike, Poole Elizabeth M, Xiao Liren, Curtin Karen, Duggan David, Hsu Li, Makar Karen W, Peters Ulrike, Kulmacz Richard J, Potter John D, Koepl Lisel, Caan Bette J, Slattery Martha L, Ulrich Cornelia M

Abstract excerpt

Glutathione peroxidases (GPXs) are selenium-dependent enzymes that reduce and, thus, detoxify hydrogen peroxide and a wide variety of lipid hydroperoxides. We investigated tagSNPs in GPX1-4 in relation to colorectal neoplasia in three independent study populations capturing the range of colorectal carcinogenesis from adenoma to cancer. A linkage-disequilibrium (LD)-based tagSNP selection algorithm (r(2) ≥ 0.90,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione Peroxidase

Share to Linkage Disequilibrium

Share to Logistic Models

Share to Principal Component Analysis

Share to Rectal Neoplasms

Share to Surveys and Questionnaires

Source

Open in PubMed Open full text

Identifiers

PMID: 22371331
DOI: 10.1002/gcc.21946
PMCID: PMC3523169

Genes

GPX3
GPX1
GPX2
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glutathione peroxidase tagSNPs: associations with rectal cancer but not with colon cancer.PMID 22371331Read ↗

Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma.Semantic proximity Read ↗

Genetic variation in selenoprotein genes, lifestyle, and risk of colon and rectal cancer.Semantic proximity Read ↗

A population-based association study of SNPs of GSTP1, MnSOD, GPX2 and Barrett's esophagus and esophageal adenocarcinoma.Semantic proximity Read ↗

GPX4 predicts poor prognosis and regulates tumor proliferation and senescence in colorectal adenocarcinomaSemantic proximity Read ↗

GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility: evidence from meta-analysis.Semantic proximity Read ↗

Genetic variation in GPX1 is associated with GPX1 activity in a comprehensive analysis of genetic variations in selenoenzyme genes and their activity and oxidative stress in humans.Semantic proximity Read ↗

The rs1050450 C > T polymorphism of GPX1 is associated with the risk of bladder but not prostate cancer: evidence from a meta-analysis.Semantic proximity Read ↗

GPX1 gene Pro200Leu polymorphism, erythrocyte GPX activity, and cancer risk.Semantic proximity Read ↗

Insights into the role of GPX3, a highly efficient plasma antioxidant, in cancer.Semantic proximity Read ↗

GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer.Semantic proximity Read ↗

The Role of rs713041 Glutathione Peroxidase 4 (GPX4) Single Nucleotide Polymorphism on Disease Susceptibility in Humans: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

The influence of selenium and selenoprotein gene variants on colorectal cancer risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.